High quality plant extracts allow Unilever to choose Golden Horizon Biologics Plant extracts had become a consensus that natural plant extracts are good for health. Plant extracts are rich in more than 500 biochemical components such as vitamins, minerals and amino acids. Therefore, many institution
Rhodiola Rosea Extract Anti-depressionDepression is a disordered mental illness caused by a variety of causes, mainly characterized by low mood, high incidence, easy recurrence, and serious harm. At present, the main treatment for depression is chemical drugs. Although the effect is obvious, it has
Rosavin is an extract product of the roots of Rhodiola rosea. The most important of these are phenylpropyl esters and flavonoids. Phenylpropyl esters include rosavin, sosin, rhodiolain; salidroside and its aglycone, in addition to starch, protein, fat, tannin, flavonoids, phenolic compounds and trac
Rhodiola rosea has been used in China for many years as an anti-depressant and anti-fatigue health food. Recent studies have shown that Rhodiola rosea extract (RCE) has cognitive protective effects on Alzheimer's disease (AD). Associate Professor Han Fei from Shenyang Pharmaceutical University recently published an article entitled "Neuroprotective effects of a Rhodiola crenulata extract on amyloid-β peptides (Aβ1-42) -induced cognitive deficits in rat models of Alzheimer's disease" in Phytomedicine magazine. The protective role of cognitive deficits and elucidation of its therapeutic mechanism in Aβ1-42-induced AD rat models. The test used lyophilization to prepare RCE. The learning and memory ability of Aβ1-42 induced AD rat model was tested by Y maze and Morris water maze (MWM) test. Subsequently, the mechanism of action was elucidated by biochemical analysis, HE staining, Western blotting and immunohistochemistry . The results showed that RCE can significantly increase the spontaneous transformation behavior of AD rats, prolong swimming time and reduce latency. In addition, RCE significantly increased acetylcholine (Ach) levels and choline acetyltransferase (ChAT) activity, repaired hippocampal neuronal damage and prevented the formation of Aβ in the hippocampus after Aβ1-42 injection in rats. Moreover, RCE increased the activity of superoxide dismutase (SOD) in the cortex of AD rat model, decreased the level of malondialdehyde (MDA) in the cortex, and significantly reduced the expression and induction of p-tau (ser396) in the hippocampus. Expression of -GSK3β (ser9). In summary, RCE can significantly attenuate the learning and memory deficits induced by Aβ1-42 in AD rats, and its mechanism of action includes protection against cholinergic system defects, oxidative stress damage and GSK3β activation, suggesting that RCE may be A multi-target potential therapeutic drug that prevents progression of AD cognitive function progression.