You are here: Home » News » General Knowledge » Natural Compounds May Carry Therapeutical Benefits for Huntington’s
November 07, 2018
Research on Effect of Soybean & Green Tea Intercropping
Research on Effect of soybean & green tea intercropping ------Golden Horizon Biologics Welcome to our green tea plantation:GHB operates its own plantations and laboratory since 2015. We always focus on how to bring natural extracts to the world. Our main natural extracts incl
January 10, 2020
2020 Exhibition Schedule--Golden Horizon Biologics
We're highly grateful to your supports to our expanding partnership. Looking forward to a prosperous 2020 with you! Stay tuned!Are you going to show up at events that listed below in 2020? Please drop me a line, and we’ll be extremely happy to meet you there:Natrual Prodcuts Expo West, Mar 3rd-7th,
September 09, 2021
Can Freeze-Dried Fruits And Vegetables Be The "New Favorite" Of The Fruit Industry Instead Of Fruits And Vegetables?
Vegetables and fruits are indispensable foods in people's daily life. Wouldn't it be better if fruits and vegetables can be made into snacks, which are easy to carry and eat at any time? The emergence of freeze-dried fruits and vegetables makes it possible to snack on fruits and vegetables. This met

Natural Compounds May Carry Therapeutical Benefits for Huntington’s

Views:9     Author:Golden Horizon (Chengdu) Technology Co., Ltd.     Publish Time: 2017-11-07      Origin:Golden Horizon (Chengdu) Technology Co., Ltd.

As therapeutics for Huntington’s disease (HD) are still a need, a number of natural compounds may hold promising beneficial effects, a review study shows.


The review “The Medicinal Chemistry of Natural and Semi-Synthetic Compounds Against Parkinson’s and Huntington’s Diseases” was published in the journal ACS Chemical Neuroscience.


As populations in western societies are increasingly older, there also is a rise in neurodegenerative diseases. Dementia is an ubiquitous hallmark of several of these conditions, including HD. The authors characterize dementia as “a general term for loss of memory and other mental abilities severe enough to interfere with daily life. It is caused by physical changes in the brain,” and there is an urgent need to find therapeutic strategies that can counteract dementia’s rising numbers, they wrote.


A team of researchers performed a review analysis of the currently available molecules (or combination of molecules) of a natural origin undergoing investigation for Huntington’s and Parkinson’s diseases. They searched for peer-reviewed articles using different online databases.


“Two major parameters were considered for the preparation of this review: particular attention was reserved to these research works presenting well-defined molecular mechanisms for the studied compounds, and, where available, papers reporting in vivo data were preferred,” authors wrote.


HD is caused by a genetic mutation in the gene encoding the huntingtin (HTT) protein and is characterized by different clinical signs, such as progressive motor, behavioral and cognitive declines. Dementia in these patients manifests in slow thought processes and executive dysfunction, and problems with attention and performance.


Currently, there are no available therapies for slowing disease progression. Since the disease is marked by a disruption of the normal levels of certain neurotransmitters, in particular dopamine, glutamate and gamma-aminobutyric acid, the majority of available therapeutics aim to restore the levels of neurotransmitters to physiological (normal) levels.


The only U.S. Food and Drug Administration (FDA)-approved drugs for one of the most debilitating symptoms of Huntington’s disease – chorea (abnormal involuntary movement) — are Xenazine (tetrabenazine) and Austedo (deutetrabenazine). Another drug that also is used as therapy to reduce chorea is Symmetrel (amantadine).


As the disease progresses, chorea coexists with, and gradually is replaced by, symptoms of Parkinsonian features, such as bradykinesia (slow movement), rigidity, and postural instability. At this stage, other therapeutic options are considered and may include Levodopa.


“Considering the actual opportunities of treatment and the fact that none of these are really effective on the aetio-pathologic mechanism of HD, [it] seems to be urgent the development of new pharmacological strategies able to block the progression of this pathology should be considered,” authors wrote.


At the moment, there are a couple of natural compounds under investigation as potential therapies for Huntington’s. These include xyloketal B, a marine compound isolated from marine mangrove fungi and some synthetic derivatives. These molecules showed a protective effect in a worm (Caenorhabditis elegans) model of human HD. They are thought to interfere with the aggregation of the abnormal HTT protein.


Neferine, a compound isolated from the aquatic plant Indian lotus (Nelumbo nucifera) also may help remove the neurotoxic protein aggregates that underlie HD by activating an intracellular degradation pathway called autophagy.


More recent studies suggest that natural molecules targeting a class on enzymes (proteins) called caspases  also are a potential therapeutical strategy for HD. Caspases, particularly caspase-1 and caspase-3, have been linked to progression of neurodegenerative diseases. In fact, in animal models of HD, these enzymes were found to be highly active. As such, a set of small natural molecules – rosmarinic acid, curcumin, luteolin, huperzine A – are undergoing investigation as potential caspase inhibitors.


“Nature gives us the possibility to experiment with different structures that have a degree of complexity and heterogeneity which are difficult to obtain with a pure synthetic approach. For this reason, the use of natural compounds or natural derived molecules can lay the foundation for a new pharmacological approach for the treatment of these pathologies,” the authors concluded.

  • Dietary Supplements
  • Food & Beverage
  • Animal Feed Additive
  • Flavor&Fragrance



 Tel: +86 28-86981346
 Phone: +86 13708068125
 Add: Unit  410, Floor4, Towers 2 Building, Hong Xing Guo Ji, No 69, Qingyun South Road, Jinjiang District, ChengDu, P.R. China, 610021


Be the first to know about our lastest products.

Copyright © Golden Horizon Technology Co., Ltd.               Terms & Conditions